LPHN3 antibody (AA 572-586)

Catalog No. ABIN7581821

Product Details anti-LPHN3 Antibody

Target: LPHN3 (Latrophilin 3 (LPHN3))

Binding Specificity: AA 572-586

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LPHN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: A Rabbit Polyclonal Antibody to Latrophilin-3

Sequence: (C)REIMWFKTRQ GQVAK

Predicted Reactivity: Rat - identical,Human- 14,15 identical

Characteristics: Anti-Latrophilin-3 (extracellular) Antibody (ABIN7581821) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Latrophilin-3 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)REIMWFKTRQGQVAK, corresponding to amino acid residues 572 - 586 of mouse Latrophilin-3

Isotype: IgG

Application Details

Application Notes: Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for LPHN3

Target: LPHN3 (Latrophilin 3 (LPHN3))

Alternative Name: ADGRL3 (LPHN3 Products)

Background: Adhesion G Protein-Coupled Receptor L3, ADGRL3, Calcium-Independent Alpha-Latrotoxin Receptor 3, LPHN3, Lectomedin-3,Latrophilin-3 (LPHN3), also known as ADGRL3, is a member of the adhesion G-protein-coupled receptor (aGPCR) family. This family is characterized by the presence of a GPCR autoproteolysis-inducing (GAIN) domain that facilitates receptor cleavage and activation, along with seven transmembrane domains1,3. LPHN3 is primarily localized to the cell membrane and is prominently expressed in neurons, with high levels observed in brain regions such as the hippocampus and prefrontal cortex1,5. LPHN3 plays critical roles in neuronal development and synapse formation. It mediates its effects through dual mechanisms: coupling with intracellular G-proteins, particularly Gαs and Gα12/13, and recruiting phase-separated postsynaptic protein scaffolds. Activation of LPHN3 is triggered by interactions with its ligands, such as teneurins and FLRTs, which enhance synaptic clustering by promoting scaffold protein condensates. Alternative splicing of Lphn3, studied in mouse models, modulates these pathways, influencing synaptic connectivity and neuronal activity3,4. Biologically, LPHN3 is involved in attention regulation and motor control, with its dysregulation linked to attention deficit hyperactivity disorder (ADHD). Genetic variants in LPHN3 are associated with altered dopaminergic signaling and increased susceptibility to ADHD, as demonstrated in human studies1,2. Furthermore, LPHN3 dysfunction has been implicated in substance use disorders and learning deficits, underscoring its importance in neuropsychiatric and cognitive processes2,5.

Gene ID: 319387

UniProt: Q80TS3