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CADM1 antibody (Extracellular)

The Rabbit Polyclonal anti-CADM1 antibody has been validated for WB, IHC, FACS and LCI. It is suitable to detect CADM1 in samples from Mouse.
Catalog No. ABIN7581839

Quick Overview for CADM1 antibody (Extracellular) (ABIN7581839)

Target

See all CADM1 Antibodies
CADM1 (Cell Adhesion Molecule 1 (CADM1))

Reactivity

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Mouse

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This CADM1 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)
  • Binding Specificity

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    AA 148-163, Extracellular

    Purpose

    A Rabbit Polyclonal antibody to CADM1/SynCAM (extracellular)

    Sequence

    (C)RNLMIDIQKD TAVEGE

    Specificity

    Extracellular, N-term.

    Predicted Reactivity

    Rat,human - identical

    Characteristics

    Anti-CADM1/SynCAM (extracellular) Antibody (ABIN7581839) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize CADM1 from mouse, rat and human samples.

    Purification

    Affinity purified on immobilized antigen.

    Immunogen

    (C)RNLMIDIQKDTAVEGE, corresponding to amino acid residues 148 - 163 of mouse CADM1 

    Isotype

    IgG
  • Application Notes

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

    Application Dilutions Western blot wb: 1:500

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    0.2 mL double distilled water (DDW).

    Concentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Storage

    4 °C,-20 °C

    Storage Comment

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    CADM1 (Cell Adhesion Molecule 1 (CADM1))

    Alternative Name

    CADM1

    Background

    Cell Adhesion Molecule 1, Synaptic Cell Adhesion Molecule, Nectin-Like 2, NECL-2, Immunoglobulin Superfamily Member 4, IgSF4,SynCAMs are a family of 4 proteins (SynCAM1-4) belonging to the immunoglobulin superfamily of cell adhesion molecules (IgCAMs) and are encoded by the cell adhesion molecule 1-4 (CADM1-4) genes1-3.Evolutionarily, SynCAMs are a fairly recent gene lineage since they are only found in vertebrates1, in contrast to much older synaptogenic adhesion molecules such as neuroligins, which appeared concurrently with the evolution of the first synapses around one billion years ago, or compared to even older protosynaptic adhesion molecules including neurexins and NCAM4.CADM1 (also known as SynCAM1), by far the most studied family member, was identified nearly simultaneously in multiple tissue types and therefore is known by a number of different protein names including immunoglobulin subfamily member 4 (IGSF4)5, spermatogenic immunoglobulin superfamily (SgIGSF)6, and RA1757.CADM1 was also initially discovered as a tumor suppressor gene and termed tumor suppressor in non-small cell lung cancer (TSLC1)8. In fact, CADM1 is downregulated in several tumors including lung, ovarian, hepatocellular carcinoma and glioblastoma, and has been proposed as both a biomarker of malignancy and a therapeutic target9.In addition, CADM1 knockout mice have impaired ultrasonic vocalization, a method for mother-offspring communication, which supports a role for CADM1 in autism spectrum disorders (ASD)10.

    Gene ID

    54725

    UniProt

    Q8R5M8

    Pathways

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
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