GPR26 antibody (Intracellular)

Catalog No. ABIN7581889

This Rabbit Polyclonal antibody specifically detects GPR26 in WB and IHC. It exhibits reactivity toward Rat.

Quick Overview for GPR26 antibody (Intracellular) (ABIN7581889)

Target: GPR26 (G Protein-Coupled Receptor 26 (GPR26))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR26 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GPR26 Antibody

Binding Specificity: AA 315-329, Intracellular

Purpose: A Rabbit Polyclonal antibody to GPR26

Sequence: (C)RRSIHSVGLT GDSHS

Specificity: Intracellular, C-terminus.

Predicted Reactivity: Mouse,Human - 14,15 identical

Characteristics: Anti-GPR26 Antibody (ABIN7581889) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR26 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RRSIHSVGLTGDSHS, corresponding to amino acid residues 315 -329 of rat GPR26

Isotype: IgG

Application Details

Application Notes: Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for GPR26

Target: GPR26 (G Protein-Coupled Receptor 26 (GPR26))

Alternative Name: GPR26

Background: G Protein-Coupled Receptor 26,GPR26, also known as G protein-coupled receptor 26, is part of the extensive G protein-coupled receptor (GPCR) superfamily, characterized by seven transmembrane domains¹. These receptors primarily mediate cellular responses to various extracellular signals, such as hormones and neurotransmitters, by coupling with intracellular G proteins, leading to signal transduction cascades1,3. GPR26 exhibits high basal activity, stimulating cyclic AMP (cAMP) production in an agonist-independent manner3. It is predominantly expressed in the central nervous system, particularly in the hypothalamus, amygdala, cortex, and striatum3,5. Cellularly, it localizes to neurons and is involved in central nervous system processes2,4. Functionally, GPR26 modulates energy balance via hypothalamic AMPK signaling and influences mood regulation by phosphorylating CREB in the amygdala2,5. p>Inactivation of GPR26 in animal models demonstrates its role in obesity, anxiety, and depression. In vitro, its loss enhances hypothalamic activity, causing hyperphagia and metabolic dysregulation, while in vivo, it leads to reduced phosphorylated CREB levels, contributing to anxiety and depression-like behaviors2,5. Aberrant GPR26 function is implicated in glioblastomas due to epigenetic silencing, linking it to tumorigenesis1. It is also associated with neurodegenerative diseases, where it participates in intranuclear inclusion formation in neurons and glial cells4. Research on GPR26 benefits areas like neuropsychiatric disorders, metabolic diseases, cancer, and neurodegeneration, where its detection and functional studies may inform therapeutic developments1,3.

Gene ID: 192153

UniProt: Q9QXI3