Neuroligin 1 antibody (AA 718-843) (FL490)

Catalog No. ABIN7595501

This Mouse Monoclonal antibody specifically detects Neuroligin 1 in IHC and ICC. It exhibits reactivity toward Rat.

Quick Overview for Neuroligin 1 antibody (AA 718-843) (FL490) (ABIN7595501)

Target: Neuroligin 1 (NLGN1)

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuroligin 1 antibody is conjugated to FL490

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N97A-31

Product Details anti-Neuroligin 1 Antibody (FL490)

Binding Specificity: AA 718-843

Purpose: Anti-Neuroligin-1 Antibody FL490 Conjugate

Specificity: No off-targets reported for Neuroligin-2, -3, -4 or -4*

Cross-Reactivity: Chicken, Human, Mouse, Rat

Characteristics:

Description: Our Anti-Neuroligin-1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N97A/31. It is KO validated, detects mouse and rat Neuroligin-1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Neuroligin-1 mouse monoclonal primary antibody from hybridoma clone N97A/31. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 718-843 (intracellular C-terminus) of rat Neuroligin-1 (accession number NP_446320) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for Neuroligin 1

Target: Neuroligin 1 (NLGN1)

Alternative Name: Neuroligin-1

Background:

Synonyms: Neuroligin-1 (Neuroligin I)

Target Description: Neuroligin 1 is a member of a large family of alternatively sliced proteins located at the post synaptic surface in the central nervous system, and stains as a post synaptic marker. Neuroligin 1 is involved in cell-cell-interactions by binding to neurexin family members and other postsynaptic proteins to localize receptors and channels in the postsynaptic density. Suggested roles for Neuroligin 1 include synapse function and synaptic signal transmission and maintaining synapse integrity. Mutations in Neuroligans have been implicated in autism and other cognitive disorders.

Gene Name Alternatives: Nlgn1

Molecular Weight: 120 kDa

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis