CNTNAP2 antibody (Extracellular Domain) (FL550)

Catalog No. ABIN7595648

This Mouse Monoclonal antibody specifically detects CNTNAP2 in IHC and ICC. It exhibits reactivity toward Human.

Quick Overview for CNTNAP2 antibody (Extracellular Domain) (FL550) (ABIN7595648)

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CNTNAP2 antibody is conjugated to FL550

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: K67-25

Product Details anti-CNTNAP2 Antibody (FL550)

Binding Specificity: Extracellular Domain

Purpose: Anti-CASPR2 Antibody FL550 Conjugate

Specificity: No off-targets reported for Caspr/paranodin

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-CASPR2 mouse monoclonal primary antibody is produced in-house from hybridoma clone K67/25. It is KO validated, detects human, mouse, and rat CASPR2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our CASPR2 mouse monoclonal primary antibody from hybridoma clone K67/25. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7) produced recombinantly in E. Coli

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Alternative Name: CASPR2

Background:

Synonyms: Contactin associated protein-like 2 (Contactin associated protein-like 2, isoform CRA_b)

Target Description: Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell-cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy.

Gene Name Alternatives: CNTNAP2 hCG_15499 tcag7.496

Molecular Weight: 180 kDa