Ankyrin G antibody (FL550)

Catalog No. ABIN7595663

This Mouse Monoclonal antibody specifically detects Ankyrin G in IHC and ICC. It exhibits reactivity toward Human.

Quick Overview for Ankyrin G antibody (FL550) (ABIN7595663)

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ankyrin G antibody is conjugated to FL550

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N106-36

Product Details anti-Ankyrin G Antibody (FL550)

Purpose: Anti-Ankyrin-G (Staining) Antibody FL550 Conjugate

Specificity: No off-targets reported for Ankyrin-B

Cross-Reactivity: Cat, Hamster, Human, Mouse, Non-Human Primate, Rat

Characteristics:

Description: Our Anti-Ankyrin-G (Staining) mouse monoclonal primary antibody is produced in-house from hybridoma clone N106/36. It detects feline, hamster, human, mouse, non-human primate, and rat Ankyrin-G (Staining), and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Ankyrin-G (Staining) mouse monoclonal primary antibody from hybridoma clone N106/36. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein ~1000 amino acids of Ankyrin-G (accession number E9PE32) produced recombinantly in E. Coli

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for Ankyrin G

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Alternative Name: Ankyrin-G

Background:

Synonyms: Ankyrin-3 (ANK-3) (Ankyrin-G)

Target Description: Ankyrin-G (ankyrin 3) is a member of the Ankyrin family which consists of Ankyrin R (1), Ankyrin B (2) and Ankyrin G (3) all of which are expressed in the nervous system. Ankyrins are structural proteins that aid in the attachment of integral membrane proteins with the spectrin-actin cytoskeleton, and thus targets voltage-gated sodium channels, potassium channels, cell adhesion molecules and others at the nodes of Ranvier and axonal initial segments (AIS). Variants in Ankyrin G have been linked to bipolar disorder.

Gene Name Alternatives: ANK3

Molecular Weight: <200 kDa

Pathways: Synaptic Membrane, Maintenance of Protein Location, Skeletal Muscle Fiber Development