MFN1 antibody (AA 350-580) (FL594)

Catalog No. ABIN7595710

This anti-MFN1 antibody is a Mouse Monoclonal antibody detecting MFN1 in ICC. Suitable for Mouse.

Quick Overview for MFN1 antibody (AA 350-580) (FL594) (ABIN7595710)

Target: MFN1 (Mitofusin 1 (MFN1))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MFN1 antibody is conjugated to FL594

Application: Immunocytochemistry (ICC)

Clone: N111-24

Product Details anti-MFN1 Antibody (FL594)

Binding Specificity: AA 350-580

Purpose: Anti-Mitofusin-1 Antibody FL594 Conjugate

Specificity: No off-targets reported for Mitofusin-2

Cross-Reactivity: Mouse, Rat

Characteristics:

Description: Our Anti-Mitofusin-1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N111/24. It is KO validated, detects mouse and rat Mitofusin-1, and is purified by Protein A chromatography. It is great for use in ICC.

Manufacturer Comment: We produce our Mitofusin-1 mouse monoclonal primary antibody from hybridoma clone N111/24. It is great in ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 350-580 of mouse Mitofusin-1 (accession number Q811U4) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for MFN1

Target: MFN1 (Mitofusin 1 (MFN1))

Alternative Name: Mitofusin-1

Background:

Synonyms: Mitofusin-1 (EC 3.6.5.-) (Transmembrane GTPase MFN1)

Target Description: Mitofusin 1, or transmembrane GTPase Mfn1 (MFN1) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria in many tissues, including heart and testis. Diseases associated with MFN1 include Optic Atrophy 1 and Autosomal Recessive Spastic Paraplegia .

Gene Name Alternatives: Mfn1

Molecular Weight: 80 kDa