HCN2 antibody (AA 761-863) (FL594)

Catalog No. ABIN7595767

This anti-HCN2 antibody is a Mouse Monoclonal antibody detecting HCN2 in IHC and ICC. Suitable for Rat.

Quick Overview for HCN2 antibody (AA 761-863) (FL594) (ABIN7595767)

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HCN2 antibody is conjugated to FL594

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N71-37

Product Details anti-HCN2 Antibody (FL594)

Binding Specificity: AA 761-863

Purpose: Anti-HCN2 Antibody FL594 Conjugate

Specificity: No off-targets reported for HCN1

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-HCN2 mouse monoclonal primary antibody is produced in-house from hybridoma clone N71/37. It detects mouse and rat HCN2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our HCN2 mouse monoclonal primary antibody from hybridoma clone N71/37. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2 (accession number Q9JKA9) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for HCN2

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Alternative Name: HCN2

Background:

Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Target Description: HCN2 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN2 is expressed throughout the brain and in high levels in thalamic and brainstem nuclei.

Gene Name Alternatives: Hcn2

Molecular Weight: 95 kDa