PSMA6 antibody (AA 1-246)

Catalog No. ABIN7599151

This Rabbit Polyclonal antibody specifically detects PSMA6 in WB, IF, ELISA and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PSMA6 antibody (AA 1-246) (ABIN7599151)

Target: PSMA6 (Proteasome Subunit alpha 6 (PSMA6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Product Details anti-PSMA6 Antibody

Binding Specificity: AA 1-246

Purpose: Anti-PSMA6 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-PSMA6 Antibody Picoband® (ABIN7599151). Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PSMA6 recombinant protein (Position: M1-D246). Human PSMA6 shares 99.6% and 100% amino acid (aa) sequence identity with mouse and rat PSMA6, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL
1. Bey, F., Silva Pereira, I., Coux, O., Viegas-Pequignot, E., Recillas Targa, F., Nothwang, H. G., Dutrillaux, B., Scherrer, K. The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. Molec. Gen. Genet. 237: 193-205, 1993. 2. Coux, O., Tanaka, K., Goldberg, A. L. Structure and functions of the 20S and 26S proteasomes. Ann. Rev. Biochem. 65: 801-847, 1996. 3. DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A., Slaughter, C. A. The primary structures of four subunits of the human, high molecular weight proteinase, macropain (proteasome), are distinct but homologous. Biochim. Biophys. Acta 1079: 29-38, 1991.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for PSMA6

Target: PSMA6 (Proteasome Subunit alpha 6 (PSMA6))

Alternative Name: PSMA6

Background:

Synonyms: PSMA6, PROS27, Proteasome subunit alpha type-6, EC 3.4.25.1, 27 kDa prosomal protein, PROS-27, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.

Molecular Weight: 27 kDa

Gene ID: 5687

UniProt: P60900

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA