GRB10 antibody (AA 1-251)

Catalog No. ABIN7599161

The Mouse Monoclonal anti-GRB10 antibody has been validated for WB and FACS. It is suitable to detect GRB10 in samples from Human, Rat and Monkey.

Quick Overview for GRB10 antibody (AA 1-251) (ABIN7599161)

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Reactivity: Human, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRB10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 5H7

Product Details anti-GRB10 Antibody

Binding Specificity: AA 1-251

Purpose: Anti-GRB10 Antibody (monoclonal, 5H7)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-GRB10 Antibody (monoclonal, 5H7) (ABIN7599161). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GRB10 recombinant protein (Position: M1-K251).

Isotype: IgG1

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Monkey, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for GRB10

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Alternative Name: GRB10

Background:

Synonyms: Deoxycytidine kinase, dCK, DCK

Tissue Specificity: Expressed ubiquitously in normal tissues.

Background: GRB10, Growth factor receptor-bound protein 10, also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 67 kDa

Gene ID: 2887

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2