FADS1 antibody (AA 1-257)

Catalog No. ABIN7599175

This Rabbit Polyclonal antibody specifically detects FADS1 in WB, ELISA, IHC, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for FADS1 antibody (AA 1-257) (ABIN7599175)

Target: FADS1 (Fatty Acid Desaturase 1 (FADS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FADS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-FADS1 Antibody

Binding Specificity: AA 1-257

Purpose: Anti-FADS1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FADS1 Antibody Picoband® (ABIN7599175). Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FADS1 recombinant protein (Position: M1-M257).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ameur, A., Enroth, S., Johansson, A., Zaboli, G., Igl, W., Johansson, A. C. V., Rivas, M. A., Daly, M. J., Schmitz, G., Hicks, A. A., Meitinger, T., Feuk, L., van Duijn, C., Oostra, B., Pramstaller, P. P., Rudan, I., Wright, A. F., Wilson, J. F., Campbell, H., Gyllensten, U. Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. Am. J. Hum. Genet. 90: 809-820, 2012. 2. Cho, H. P., Nakamura, M., Clarke, S. D. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J. Biol. Chem. 274: 37335-37339, 1999. 3. Marquardt, A., Stohr, H., White, K., Weber, B. H. F. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-183, 2000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FADS1

Target: FADS1 (Fatty Acid Desaturase 1 (FADS1))

Alternative Name: FADS1

Background:

Synonyms: Natural killer cell receptor 2B4, Cd244, LOC685808

Tissue Specificity: Expressed in natural killer (NK) cells, T cells and dendritic cells.

Background: Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene. The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1, this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Molecular Weight: 52 kDa

Gene ID: 3992

UniProt: O60427

Pathways: Regulation of Lipid Metabolism by PPARalpha