MAML1 antibody (AA 1-998)

Catalog No. ABIN7599584

The Rabbit Polyclonal anti-MAML1 antibody has been validated for ELISA and WB. It is suitable to detect MAML1 in samples from Human.

Quick Overview for MAML1 antibody (AA 1-998) (ABIN7599584)

Target: MAML1 (Mastermind-Like 1 (MAML1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MAML1 Antibody

Binding Specificity: AA 1-998

Purpose: Anti-MAML1 Antibody Picoband®

Characteristics: Anti-MAML1 Antibody Picoband® (ABIN7599584). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MAML1 recombinant protein (Position: M1-K998). Human MAML1 shares 86.3% amino acid (aa) sequence identity with mouse MAML1.

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Moellering, R. E., Cornejo, M., Davis, T. N., Del Bianco, C., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., Bradner, J. E. Direct inhibition of the NOTCH transcription factor complex. Nature 462: 182-188, 2009. Note: Erratum: Nature 463: 384 only, 2010. 2. Nagase, T., Seki, N., Ishikawa, K., Tanaka, A., Nomura, N. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 3: 17-24, 1996. 3. Shen, H., McElhinny, A. S., Cao, Y., Gao, P., Liu, J., Bronson, R., Griffin, J. D., Wu, L. The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 20: 675-688, 2006.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Alternative Name: MAML1

Background: Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene. This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Molecular Weight: 130 kDa

Gene ID: 9794

UniProt: Q92585

Pathways: Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development