c-Rel antibody (AA 116-610)

Catalog No. ABIN7599778

This anti-c-Rel antibody is a Rabbit Polyclonal antibody detecting c-Rel in WB, ELISA, IF, ICC and FACS. Suitable for Human.

Quick Overview for c-Rel antibody (AA 116-610) (ABIN7599778)

Target: c-Rel (REL proto-oncogene (c-Rel))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-Rel antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-c-Rel Antibody

Binding Specificity: AA 116-610

Purpose: Anti-c-Rel/REL Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-c-Rel/REL Antibody Picoband® (ABIN7599778). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human c-Rel/REL recombinant protein (Position: K116-D610).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Beaussant-Cohen, S., Jaber, F., Massaad, M. J., Weeks, S., Jones, J., Alosaimi, M. F., Wallace, J., Al-Herz, W., Geha, R. S., Chou, J. Combined immunodeficiency in a patient with c-Rel deficiency. J. Allergy Clin. Immun. 144: 606-608, 2019. 2. Belguise, K., Sonenshein, G. E. PKC-theta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor-alpha synthesis. J. Clin. Invest. 117: 4009-4021, 2007. 3. Brownell, E., Fell, H. P., Tucker, P. W., Geurts van Kessel, A. H., Hagemeijer, A., Rice, N. R. Regional localization of the human c-rel locus using translocation chromosome analysis. Oncogene 2: 527-529, 1988.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for c-Rel

Target: c-Rel (REL proto-oncogene (c-Rel))

Alternative Name: REL

Background:

Synonyms: Programmed cell death protein 10, Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15, PDCD10, CCM3, TFAR15

Tissue Specificity: Ubiquitous.

Background: The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 78 kDa

Gene ID: 5966

UniProt: Q04864