Sulfide:quinone Oxidoreductase, Mitochondrial (SQOR) (AA 12-321) antibody

Catalog No. ABIN7599815

This Rabbit Polyclonal antibody specifically detects in IHC, ELISA, WB, FACS, ICC and IF. It exhibits reactivity toward Human.

Quick Overview for Sulfide:quinone Oxidoreductase, Mitochondrial (SQOR) (AA 12-321) antibody (ABIN7599815)

Target: Sulfide:quinone Oxidoreductase, Mitochondrial (SQOR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details

Binding Specificity: AA 12-321

Purpose: Anti-SQRDL/SQOR Antibody Picoband®

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Anti-SQRDL/SQOR Antibody Picoband® (ABIN7599815). Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SQRDL/SQOR recombinant protein (Position: R12-E321). Human SQOR shares 86.1% amino acid (aa) sequence identity with mouse SQOR.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Friederich, M. W., Elias, A. F., Kuster, A., Laugwitz, L., Larson, A. A., Landry, A. P., Ellwood-Digel, L., Mirsky, D. M., Dimmock D., Haven, J., Jiang, H., MacLean, K. N., Styren, K., Schoof, J., Goujon, L., Lefrancois, T., Friederich, M., Couglin, C. R., II, Banerjee, R., Haack, T. B., Van Hove, J. L. K. Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease. J. Inherit. Metab. Dis. 43: 1024-1036, 2020. 2. Gonzalez-Garcia, P., Hidalgo-Gutierrez, A., Mascaraque, C., Barriocanal-Casado, E., Bakkali, M., Ziosi, M., Abdihankyzy, U. B., Sanchez-Hernandez, S., Escames, G., Prokish, H., Martin, F., Quinzii, C. M., Lopez, L. C. Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism. Hum. Molec. Genet. 29: 3296-3311, 2020. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 09/01/2017.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details

Target: Sulfide:quinone Oxidoreductase, Mitochondrial (SQOR)

Alternative Name: SQOR

Background:

Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Tissue Specificity: Expressed in all tissues.

Background: The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein.

Molecular Weight: 50 kDa

Gene ID: 58472

UniProt: Q9Y6N5