IQSEC2 antibody (AA 122-1396)

Catalog No. ABIN7599847

This anti-IQSEC2 antibody is a Rabbit Polyclonal antibody detecting IQSEC2 in ELISA and WB. Suitable for Mouse and Rat.

Quick Overview for IQSEC2 antibody (AA 122-1396) (ABIN7599847)

Target: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IQSEC2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-IQSEC2 Antibody

Binding Specificity: AA 122-1396

Purpose: Anti-IQSEC2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-IQSEC2 Antibody Picoband® (ABIN7599847). Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human IQSEC2 recombinant protein (Position: A122-M1396). Human IQSEC2 shares 98.2% amino acid (aa) sequence identity with mouse IQSEC2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL
1. de Vries, B. B. A., Breedveld, G. J., Deelen, W. H., Niermeijer, M. F., Heutink, P., Breuning, M. H. Another family with nonspecific X-linked mental retardation (MRX78) maps to Xp11.4-p11.23. Am. J. Med. Genet. 111: 443-445, 2002. Note: Erratum: Am. J. Med. Genet. 113: 391 only 2002. 2. Filippova, G. N., Cheng, M. K., Moore, J. M., Truong, J.-P., Hu, Y. J., Nguyen, D. K., Tsuchiya, K. D., Disteche, C. M. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev. Cell 8: 31-42, 2005. 3. Gedeon, A., Kerr, B., Mulley, J., Turner, G. Pericentromeric genes for non-specific X-linked mental retardation (MRX). Am. J. Med. Genet. 51: 553-564, 1994.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for IQSEC2

Target: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Alternative Name: IQSEC2

Background:

Synonyms: IQSEC2, KIAA0522, IQ motif and SEC7 domain-containing protein 2

Background: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 163 kDa

Gene ID: 23096