CTNNBL1 antibody (AA 122-231)

Catalog No. ABIN7599851

This Rabbit Polyclonal antibody specifically detects CTNNBL1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for CTNNBL1 antibody (AA 122-231) (ABIN7599851)

Target: CTNNBL1 (Catenin, beta Like 1 (CTNNBL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNNBL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-CTNNBL1 Antibody

Binding Specificity: AA 122-231

Purpose: Anti-CTNNBL1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-CTNNBL1 Antibody Picoband® (ABIN7599851). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CTNNBL1 recombinant protein (Position: Q122-E231). Human CTNNBL1 shares 97.3% and 98.2% amino acid (aa) sequence identity with mouse and rat CTNNBL1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Conticello, S. G., Ganesh, K., Xue, K., Lu, M., Rada, C., Neuberger, M. S. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Molec. Cell 31: 474-484, 2008. 2. Ganesh, K., Adam, S., Taylor, B., Simpson, P., Rada, C., Neuberger, M. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. J. Biol. Chem. 286: 17091-17102, 2011. 3. Jabbour, L., Welter, J. F., Kollar, J., Hering, T. M. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics 81: 292-303, 2003.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for CTNNBL1

Target: CTNNBL1 (Catenin, beta Like 1 (CTNNBL1))

Alternative Name: CTNNBL1

Background:

Synonyms: CTNNBL1, C20orf33, PP8304, Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19

Background: Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.

Molecular Weight: 65 kDa

Gene ID: 56259

Pathways: Production of Molecular Mediator of Immune Response