VWF antibody (AA 1287-2770)

Catalog No. ABIN7599909

The Rabbit Polyclonal anti-VWF antibody has been validated for IHC and ELISA. It is suitable to detect VWF in samples from Human.

Quick Overview for VWF antibody (AA 1287-2770) (ABIN7599909)

Target: VWF (Von Willebrand Factor (VWF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VWF antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-VWF Antibody

Binding Specificity: AA 1287-2770

Purpose: Anti-Von Willebrand Factor/VWF Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Von Willebrand Factor/VWF Antibody Picoband® (ABIN7599909). Tested in ELISA, IHC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Von Willebrand Factor/VWF recombinant protein (Position: R1287-Q2770).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Sadler JE (1998). "Biochemistry and genetics of von Willebrand factor". Annu. Rev. Biochem. 67: 395-424. 2. Ginsburg, D., Handin, R. I., Bonthron, D. T., Donlon, T. A., Bruns, G. A. P., Latt, S. A., Orkin, S. H. Human von Willebrand factor (VWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science 228: 1401-1406, 1985. 3. Sporn, L. A., Marder, V. J., Wagner, D. D. Von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Blood 69: 1531-1534, 1987.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for VWF

Target: VWF (Von Willebrand Factor (VWF))

Alternative Name: VWF

Background:

Synonyms: Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, Forkhead box protein A1, Transcription factor 3A, TCF-3A, FOXA1, HNF3A, TCF3A

Tissue Specificity: Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

Background: Von Willebrand factor (VWF) is a blood glycoprotein involved in hemostasis. It is mapped to 12p13.31. The VWF gene encodes von Willebrand factor (VWF), a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. VWF deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.

Molecular Weight: 49 kDa

Gene ID: 7450

UniProt: P04275