RRM1 antibody (AA 129-730)

Catalog No. ABIN7599920

This Rabbit Polyclonal antibody specifically detects RRM1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for RRM1 antibody (AA 129-730) (ABIN7599920)

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-RRM1 Antibody

Binding Specificity: AA 129-730

Purpose: Anti-RRM1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-RRM1 Antibody Picoband® (ABIN7599920). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RRM1 recombinant protein (Position: D129-Q730).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Brissenden, J. E., Caras, I., Thelander, L., Francke, U. The structural gene for the M1 subunit of human ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. Exp. Cell Res. 174: 302-308, 1988. 2. Byrne, J. A., Smith, P. J. The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Hum. Genet. 91: 275-277, 1993. 3. Byrne, J., Smith, P. Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. Hum. Genet. 87: 376 only, 1991.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Alternative Name: RRM1

Background:

Synonyms: Semaphorin-3A, Semaphorin III, Sema III, SEMA3A, SEMAD,

Background: Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

Molecular Weight: 90 kDa

Gene ID: 6240

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity