TTDN1 antibody (AA 135-179)

Catalog No. ABIN7599981

Product Details anti-TTDN1 Antibody

Target: TTDN1 (MPLKIP) (M-Phase Specific PLK1 Interacting Protein (MPLKIP))

Binding Specificity: AA 135-179

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTDN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Purpose: Anti-MPLKIP Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-MPLKIP Antibody Picoband® (ABIN7599981). Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MPLKIP recombinant protein (Position: E135-C179). Human MPLKIP shares 97.7% amino acid (aa) sequence identity with mouse MPLKIP.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL
1. Botta, E., Offman, J., Nardo, T., Ricotti, R., Zambruno, G., Sansone, D., Balestri, P., Raams, A., Kleijer, W. J., Jaspers, N. G. J., Sarasin, A., Lehmann, A. R., Stefanini, M. Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships. Hum. Mutat. 28: 92-96, 2007. 2. Jackson, C. E., Weiss, L., Watson, J. H. L. 'Brittle' hair with short stature, intellectual impairment and decreased fertility: an autosomal recessive syndrome in an Amish kindred. Pediatrics 54: 201-212, 1974. 3. Nakabayashi, K., Amann, D., Ren, Y., Saarialho-Kere, U., Avidan, N., Gentles, S., MacDonald, J. R., Puffenberger, E. G., Christiano, A. M., Martinez-Mir, A., Salas-Alanis, J. C., Rizzo, R., Vamos, E., Raams, A., Les, C., Seboun, E., Jaspers, N. G. J., Beckmann, J. S., Jackson, C. E., Scherer, S. W. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Am. J. Hum. Genet. 76: 510-516, 2005.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TTDN1

Target: TTDN1 (MPLKIP) (M-Phase Specific PLK1 Interacting Protein (MPLKIP))

Alternative Name: MPLKIP (MPLKIP Products)

Background:

Synonyms: MPLKIP, C7orf11, TTDN1, M-phase-specific PLK1-interacting protein, TTD non-photosensitive 1 protein

Background: The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy.

Molecular Weight: 19 kDa

Gene ID: 136647