LACTB antibody (AA 141-543)

Catalog No. ABIN7600047

The Rabbit Polyclonal anti-LACTB antibody has been validated for WB, ELISA, IHC, ICC, IF and FACS. It is suitable to detect LACTB in samples from Human.

Quick Overview for LACTB antibody (AA 141-543) (ABIN7600047)

Target: LACTB (Lactamase, beta (LACTB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LACTB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-LACTB Antibody

Binding Specificity: AA 141-543

Purpose: Anti-LACTB Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-LACTB Antibody Picoband® (ABIN7600047). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LACTB recombinant protein (Position: E141-K543).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., Leonardson, A., Castellini, L. W., and 10 others. Variations in DNA elucidate molecular networks that cause disease. Nature 452: 429-435, 2008. 2. Hell-Pourmojib, M., Neuner, P., Fischer, H., Rezaie, S., Kindas-Mugge, I., Knobler, R., Trautinger, F. Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes. J. Invest. Derm. 119: 154-159, 2002. 3. Keckesova, Z., Donaher, J. L., De Cock, J., Freinkman, E., Lingrell, S., Bachovchin, D. A., Bierie, B., Tischler, V., Noske, A., Okondo, M. C., Reinhardt, F., Thiru, P., Golub, T. R., Vance, J. E., Weinberg, R. A. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature 543: 681-686, 2017.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for LACTB

Target: LACTB (Lactamase, beta (LACTB))

Alternative Name: LACTB

Background:

Synonyms: Follicular dendritic cell secreted peptide,FDC secreted protein,FDC-SP,FDCSP,C4orf7,UNQ733/PRO1419,

Tissue Specificity: Abundantly expressed in tonsil, lymph node, and trachea, strong expression in prostate, lower expression in thyroid, stomach, and colon. .

Background: Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene. This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

Molecular Weight: 54 kDa

Gene ID: 114294

UniProt: P83111