FXR2 antibody (AA 153-651)

Catalog No. ABIN7600138

This anti-FXR2 antibody is a Rabbit Polyclonal antibody detecting FXR2 in WB, ELISA and FACS. Suitable for Human, Mouse and Monkey.

Quick Overview for FXR2 antibody (AA 153-651) (ABIN7600138)

Target: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FXR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-FXR2 Antibody

Binding Specificity: AA 153-651

Purpose: Anti-FXR2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FXR2 Antibody Picoband® (ABIN7600138). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FXR2 recombinant protein (Position: N153-K651).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Monkey
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Bontekoe, C. J. M., McIlwain, K. L., Nieuwenhuizen, I. M., Yuva-Paylor, L. A., Nellis, A., Willemsen, R., Fang, Z., Kirkpatrick, L., Bakker, C. E., McAninch, R., Cheng, N. C., Merriweather, M., Hoogeveen, A. T., Nelson, D., Paylor, R., Oostra, B. A. Knockout mouse model for Fxr2: a model for mental retardation. Hum. Molec. Genet. 11: 487-498, 2002. 2. Darnell, J. C., Fraser, C. E., Mostovetsky, O., Darnell, R. B. Discrimination of common and unique RNA-binding activities among fragile X mental retardation protein paralogs. Hum. Molec. Genet. 18: 3164-3177, 2009. 3. Kirkpatrick, L. L., McIlwain, K. A., Nelson, D. L. Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2. Genomics 78: 169-177, 2001.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FXR2

Target: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Alternative Name: FXR2

Background:

Synonyms: Sodium- and chloride-dependent GABA transporter 1,GAT-1,Solute carrier family 6 member 1,SLC6A1,GABATR, GABT1, GAT1,

Tissue Specificity: Expressed in many tissues, highest levels in skeletal muscle.

Background: Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome.

Molecular Weight: 93 kDa

Gene ID: 9513

UniProt: P51116