FGF15 antibody (AA 26-218)

Catalog No. ABIN7600946

This anti-FGF15 antibody is a Rabbit Polyclonal antibody detecting FGF15 in IHC. Suitable for Rat and Mouse.

Quick Overview for FGF15 antibody (AA 26-218) (ABIN7600946)

Target: FGF15 (Fibroblast Growth Factor 15 (FGF15))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF15 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-FGF15 Antibody

Binding Specificity: AA 26-218

Purpose: Anti-Fgf19(Fgf15) Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Fgf19(Fgf15) Antibody Picoband® (ABIN7600946). Tested in IHC applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived rat Fgf19(Fgf15) recombinant protein (Position: R26-K218). Rat Fgf19(Fgf15) shares 53.2% and 96.4% amino acid (aa) sequence identity with human and mouse FGF19, respectively.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
1. Jones, SA (2012). "Physiology of FGF15/19". Advances in Experimental Medicine and Biology. 728: 171-82. 2. Potthoff, MJ, Kliewer, SA, Mangelsdorf, DJ (2012). "Endocrine fibroblast growth factors 15/19 and 21: from feast to famine". Genes & Development. 26 (4): 312-324. 3. Owen, BM, Mangelsdorf, DJ, Kliewer, SA (January 2015). "Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21". Trends in Endocrinology and Metabolism. 26 (1): 22-9.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FGF15

Target: FGF15 (Fibroblast Growth Factor 15 (FGF15))

Alternative Name: Fgf19(Fgf15)

Background:

Synonyms: Fibroblast growth factor 19,FGF-19,FGF19,UNQ334/PRO533,

Tissue Specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. .

Background: FGF15/19 refers to two orthologous fibroblast growth factors which share 50 % aminoacid identity and have similar functions. FGF15 was described in the mouse, FGF19 was found in humans and other species. They share physiological functions and so are often referred to as FGF15/19 or as FGF15/FGF19. They were first described in developing fetal brain. They are now known to be produced in the ileum, and under certain circumstances in the liver and biliary tree. It is thought their principal function is in response to bile acid absorption occurring after meals. FGF15 and FGF19 have similar roles in regulating bile acid synthesis and also glucose metabolism in the liver.

Molecular Weight: 24 kDa

Gene ID: 170582, 14170