ITGA2 antibody (AA 285-1181)

Catalog No. ABIN7601097

This Rabbit Polyclonal antibody specifically detects ITGA2 in FACS, WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for ITGA2 antibody (AA 285-1181) (ABIN7601097)

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA

Product Details anti-ITGA2 Antibody

Binding Specificity: AA 285-1181

Purpose: Anti-Integrin alpha 2/ITGA2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Integrin alpha 2/ITGA2 Antibody Picoband® (ABIN7601097). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Integrin alpha 2/ITGA2 recombinant protein (Position: E285-S1181).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bettaieb, A., Fromont, P., Rodet, M., Godeau, B., Duedari, N., Bierling, P. Br(b), a platelet alloantigen involved in neonatal alloimmune thrombocytopenia. Vox Sang. 60: 230-234, 1991. 2. Carlsson, L. E., Santoso, S., Spitzer, C., Kessler, C., Greinacher, A. The alpha-2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha-2/beta-1 might be a genetic risk factor for the development of stroke in younger patients. Blood 93: 3583-3586, 1999. 3. Fan, X., Moltedo, B., Mendoza, A., Davydov, A. N., Faire, M. B., Mazutis, L., Sharma, R., Pe'er, D., Chudakov, D. M., Rudensky, A. Y. CD49b defines functionally mature Treg cells that survey skin and vascular tissues. J. Exp. Med. 215: 2796-2814, 2018.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for ITGA2

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Alternative Name: ITGA2

Background:

Synonyms: Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11, CGI-135

Tissue Specificity: Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).

Background: Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Molecular Weight: 165 kDa

Gene ID: 3673

UniProt: P17301

Pathways: CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex