SLK antibody (AA 328-1232)

Catalog No. ABIN7601332

The Rabbit Polyclonal anti-SLK antibody has been validated for WB, ELISA, IHC and FACS. It is suitable to detect SLK in samples from Human and Mouse.

Quick Overview for SLK antibody (AA 328-1232) (ABIN7601332)

Target: SLK (STE20-Like Kinase (SLK))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-SLK Antibody

Binding Specificity: AA 328-1232

Purpose: Anti-SLK Antibody Picoband®

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Anti-SLK Antibody Picoband® (ABIN7601332). Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SLK recombinant protein (Position: E328-S1232). Human SLK shares 78.2% and 72.1% amino acid (aa) sequence identity with mouse and rat SLK, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunohistochemistry, 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. "Entrez Gene: SLK STE20-like kinase (yeast)". 2. Sabourin, L. A., Tamai, K., Seale, P., Wagner, J., Rudnicki, M. A. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Molec. Cell. Biol. 20: 684-696, 2000. Note: Erratum: Molec. Cell. Biol. 20: 2949, 2000. 3. Zhapparova, O. N., Fokin, A. I., Vorobyeva, N. E., Bryantseva, S. A., Nadezhdina, E. S. Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. Molec. Biol. Cell 24: 3205-3214, 2013. [

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for SLK

Target: SLK (STE20-Like Kinase (SLK))

Alternative Name: SLK

Background:

Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Tissue Specificity: Expressed in all tissues.

Background: STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene. This gene is mapped to chromosome 10q24.33-q25.1. SLK is a kinase with multiple functional domains that is predicted to regulate cytoskeletal organization and responses to apoptotic stimuli.

Molecular Weight: 245 kDa

Gene ID: 9748

UniProt: Q9H2G2