TMEM59 antibody (AA 37-323)

Catalog No. ABIN7601499

This Rabbit Polyclonal antibody specifically detects TMEM59 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for TMEM59 antibody (AA 37-323) (ABIN7601499)

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-TMEM59 Antibody

Binding Specificity: AA 37-323

Purpose: Anti-TMEM59 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TMEM59 Antibody Picoband® (ABIN7601499). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TMEM59 recombinant protein (Position: A37-I323).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Boada-Romero, E., Letek, M., Fleischer, A., Pallauf, K., Ramon-Barros, C., Pimentel-Muinos, F. X. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J. 32: 566-582, 2013. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 08/19/2016. 3. Ullrich, S., Munch, A., Neumann, S., Kremmer, E., Tatzelt, J., Lichtenthaler, S. F. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 285: 20664-20674, 2010.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TMEM59

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Alternative Name: TMEM59

Background:

Synonyms: B-cell differentiation antigen CD72, Lyb-2, CD72, CD72

Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Background: Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene. This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.

Molecular Weight: 44 kDa

Gene ID: 9528