FOXC1 antibody (AA 392-554)

Catalog No. ABIN7601591

This anti-FOXC1 antibody is a Rabbit Polyclonal antibody detecting FOXC1 in WB, ELISA, IF and ICC. Suitable for Human.

Quick Overview for FOXC1 antibody (AA 392-554) (ABIN7601591)

Target: FOXC1 (Forkhead Box C1 (FOXC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-FOXC1 Antibody

Binding Specificity: AA 392-554

Purpose: Anti-FOXC1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FOXC1 Antibody (ABIN7601591). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXC1 recombinant protein (Position: T392-F554).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FOXC1

Target: FOXC1 (Forkhead Box C1 (FOXC1))

Alternative Name: FOXC1

Background:

Synonyms: Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3, FOXC1, FKHL7, FREAC3

Tissue Specificity: Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090). Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501). Expressed in breast cancers (at protein level) (PubMed:26565916). Expressed in hematopoietic cells (PubMed:8499623).

Background: Forkhead box C1, also known as?FOXC1, is a?protein?which in humans is encoded by the?FOXC1?gene. It is mapped to 6p25.3. This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined, however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Molecular Weight: 75 kDa

Gene ID: 2296

UniProt: Q12948

Pathways: Chromatin Binding, Glycosaminoglycan Metabolic Process