ADAM8 antibody (AA 41-290)

Catalog No. ABIN7601664

This Rabbit Polyclonal antibody specifically detects ADAM8 in WB, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for ADAM8 antibody (AA 41-290) (ABIN7601664)

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-ADAM8 Antibody

Binding Specificity: AA 41-290

Purpose: Anti-MS2/ADAM8 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-MS2/ADAM8 Antibody Picoband® (ABIN7601664). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MS2/ADAM8 recombinant protein (Position: R41-L290).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hernandez, I., Moreno, J. L., Zandueta, C., Montuenga, L., Lecanda, F. Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer. Oncogene 29: 3758-3769, 2010. 2. Higuchi, Y., Kataoka, M., Yamamoto, S. MS2 (ADAM 8), a myelomonocytic cell surface antigen: expression, chromosomal localization and production of truncated ADAM 8 transgenic mice. (Abstract) Tissue Antigens 48: 423 only, 1996. 3. Kelly, K., Hutchinson, G., Nebenius-Oosthuizen, D., Smith, A. J. H., Bartsch, J. W., Horiuchi, K., Rittger, A., Manova, K., Docherty, A. J. P., Blobel, C. P. Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev. Dyn. 232: 221-231, 2005.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for ADAM8

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Alternative Name: ADAM8

Background:

Synonyms: Calretinin, CR, 29 kDa calbindin, CALB2, CAB29

Tissue Specificity: Brain.

Background: A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Molecular Weight: 80 kDa

Gene ID: 101

UniProt: P78325

Pathways: Activation of Innate immune Response, M Phase