NRD1 antibody (AA 427-967)

Catalog No. ABIN7601708

This anti-NRD1 antibody is a Rabbit Polyclonal antibody detecting NRD1 in WB, ELISA and FACS. Suitable for Human.

Quick Overview for NRD1 antibody (AA 427-967) (ABIN7601708)

Target: NRD1 (Nardilysin (N-Arginine Dibasic Convertase) (NRD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-NRD1 Antibody

Binding Specificity: AA 427-967

Purpose: Anti-NRD1/NRDC Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-NRD1/NRDC Antibody Picoband® (ABIN7601708). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NRD1/NRDC recombinant protein (Position: K427-R967).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Fumagalli, P., Accarino, M., Egeo, A., Scartezzini, P., Rappazzo, G., Pizzuti, A., Avvantaggiato, V., Simeone, A., Arrigo, G., Zuffardi, O., Ottolenghi, S., Taramelli, R. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics 47: 238-245, 1998. 2. Hospital, V., Prat, A., Joulie, C., Cherif, D., Day, R., Cohen, P. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. Biochem. J. 327: 773-779, 1997. 3. Ohno, M., Hiraoka, Y., Matsuoka, T., Tomimoto, H., Takao, K., Miyakawa, T., Oshima, N., Kiyonari, H., Kimura, T., Kita, T., Nishi, E. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nature Neurosci. 12: 1506-1513, 2009.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for NRD1

Target: NRD1 (Nardilysin (N-Arginine Dibasic Convertase) (NRD1))

Alternative Name: NRDC

Background:

Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38, AHSA1, C14orf3, HSPC322

Tissue Specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

Background: This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 140 kDa

Gene ID: 4898

UniProt: O43847

Pathways: Skeletal Muscle Fiber Development