alpha 2 Antiplasmin antibody (AA 461-491)

Catalog No. ABIN7601808

This Rabbit Polyclonal antibody specifically detects alpha 2 Antiplasmin in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for alpha 2 Antiplasmin antibody (AA 461-491) (ABIN7601808)

Target: alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 2 Antiplasmin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-alpha 2 Antiplasmin Antibody

Binding Specificity: AA 461-491

Purpose: Anti-Alpha 2 Antiplasmin/SERPINF2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Alpha 2 Antiplasmin/SERPINF2 Antibody Picoband® (ABIN7601808). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Alpha 2 Antiplasmin/SERPINF2 recombinant protein (Position: K461-K491).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bangert, K., Johnsen, A. H., Christensen, U., Thorsen, S. Different N-terminal forms of alpha-2-plasmin-inhibitor in human plasma. Biochem. J. 291: 623-625, 1993. 2. Favier, R., Aoki, N., de Moerloose, P. Congenital alpha-2-plasmin inhibitor deficiencies: a review. Brit. J. Haemat. 114: 4-10, 2001. 3. Hirosawa, S., Nakamura, Y., Miura, O., Sumi, Y., Aoki, N. Organization of the human alpha-2-plasmin inhibitor gene. Proc. Nat. Acad. Sci. 85: 6836-6840, 1988. Note: Erratum: Proc. Nat. Acad. Sci. 86: 1612-1613, 1989.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for alpha 2 Antiplasmin

Target: alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))

Alternative Name: SERPINF2

Background:

Synonyms: Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, FCER2, CD23A, CLEC4J, FCE2, IGEBF

Tissue Specificity: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.

Background: Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene. This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 65 kDa

Gene ID: 5345

UniProt: P08697

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones