TRMT6 antibody (AA 6-489)

Catalog No. ABIN7602138

Product Details anti-TRMT6 Antibody

Target: TRMT6 (tRNA Methyltransferase 6 Homolog (TRMT6))

Binding Specificity: AA 6-489

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRMT6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: Anti-TRMT6 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-TRMT6 Antibody Picoband® (ABIN7602138). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TRMT6 recombinant protein (Position: E6-K489).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 1-2 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Wang, Y. , Huang, Q. , Deng, T. , Li, B. H. , & Ren, X. Q. . (2019). Clinical significance of trmt6 in hepatocellular carcinoma: a bioinformatics-based study. Medical Science Monitor, 25, 3894-3901. 2. Finermoore, J. , Czudnochowski, N. , O'Connell, J. D. , Wang, A. L. , & Stroud, R. M. . (2015). Crystal structure of the human trna m1a58 methyltransferase-trna3lys complex: refolding of substrate trna allows access to the methylation target. Journal of Molecular Biology, 427(24), 3862-3876. 3. Wang, Y. , Wang, J. , Li, X. , Xiong, X. , Wang, J. , & Zhou, Z. , et al. N 1-methyladenosine methylation in trna drives liver tumourigenesis by regulating cholesterol metabolism. Nature communications, 12(1), 6314.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TRMT6

Target: TRMT6 (tRNA Methyltransferase 6 Homolog (TRMT6))

Alternative Name: TRMT6 (TRMT6 Products)

Background:

Synonyms: Follicular dendritic cell secreted peptide,FDC secreted protein,FDC-SP,FDCSP,C4orf7,UNQ733/PRO1419,

Tissue Specificity: Abundantly expressed in tonsil, lymph node, and trachea, strong expression in prostate, lower expression in thyroid, stomach, and colon. .

Background: This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants.

Molecular Weight: 60 kDa

Gene ID: 51605