NFE2L3 antibody (AA 66-653)

Catalog No. ABIN7602254

This anti-NFE2L3 antibody is a Rabbit Polyclonal antibody detecting NFE2L3 in WB and ELISA. Suitable for Mouse.

Quick Overview for NFE2L3 antibody (AA 66-653) (ABIN7602254)

Target: NFE2L3 (Nuclear Factor (erythroid-Derived 2)-Like 3 (NFE2L3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFE2L3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NFE2L3 Antibody

Binding Specificity: AA 66-653

Purpose: Anti-Nfe2l3 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Nfe2l3 Antibody Picoband® (ABIN7602254). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Nfe2l3 recombinant protein (Position: E66-K653).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Chevillard, G., Paquet, M., Blank, V. Nfe213 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood 117: 2005-2008, 2011. 2. Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., Yamamoto, M. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J. Biol. Chem. 274: 6443-6452, 1999.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for NFE2L3

Target: NFE2L3 (Nuclear Factor (erythroid-Derived 2)-Like 3 (NFE2L3))

Alternative Name: Nfe2l3

Background:

Synonyms: Interleukin-36 alpha, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, IL36A, FIL1E, IL1E, IL1F6

Tissue Specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.

Background: Nuclear factor (erythroid 2)-like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene. This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.

Molecular Weight: 76 kDa

Gene ID: 18025