CREB1 antibody (AA 7-270)

Catalog No. ABIN7602321

This Rabbit Polyclonal antibody specifically detects CREB1 in WB and ELISA. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for CREB1 antibody (AA 7-270) (ABIN7602321)

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CREB1 Antibody

Binding Specificity: AA 7-270

Purpose: Anti-CREB1 Antibody Picoband®

Characteristics: Anti-CREB1 Antibody Picoband® (ABIN7602321). Tested in WB, ELISA applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CREB1 recombinant protein (Position: A7-R270). Human CREB1 shares 99.6% and 99.2% amino acid (aa) sequence identity with mouse and rat CREB1, respectively.

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Monkey, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Antonescu, C. R., Dal Cin, P., Nafa, K., Teot, L. A., Surti, U., Fletcher, C. D., Ladanyi, M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 46: 1051-1060, 2007. 2. Barco, A., Alarcon, J. M., Kandel, E. R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108: 689-703, 2002. 3. Barton, C. H., Ajioka, J. W., Roach, T. I. A., Blackwell, J. M. Mapping Creb-1 to chromosome 1 in the mouse. Genomics 14: 790-792, 1992.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for CREB1

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Alternative Name: CREB1

Background: CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.

Molecular Weight: 43,49 kDa

Gene ID: 1385

UniProt: P16220

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation