IL18RAP antibody (C-Term)

Catalog No. ABIN7602806

This anti-IL18RAP antibody is a Rabbit Polyclonal antibody detecting IL18RAP in WB. Suitable for Human.

Quick Overview for IL18RAP antibody (C-Term) (ABIN7602806)

Target: IL18RAP (Interleukin 18 Receptor Accessory Protein (IL18RAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL18RAP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL18RAP Antibody

Binding Specificity: C-Term

Purpose: Anti-IL-18R Beta/IL-18RAP Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-IL-18R Beta/IL-18RAP Antibody Picoband® (ABIN7602806). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IL-18R Beta/IL-18RAP, which shares 84.4% amino acid (aa) sequence identity with both mouse and rat IL-18R Beta/IL-18RAP.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
1. Born, T. L., Thomassen, E., Bird, T. A., Sims, J. E. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273: 29445-29450, 1998. 2. Koskinen, L. L. E., Einarsdottir, E., Dukes, E., Heap, G. A. R., Dubois, P., Korponay-Szabo, I. R., Kaukinen, K., Kurppa, K., Ziberna, F., Vatta, S., Not, T., Ventura, A., and 9 others. Association study of the IL18RAP locus in three European populations with coeliac disease. Hum. Molec. Genet. 18: 1148-1155, 2009.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.005 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for IL18RAP

Target: IL18RAP (Interleukin 18 Receptor Accessory Protein (IL18RAP))

Alternative Name: IL18RAP

Background:

Synonyms: Sodium channel subunit beta-4, SCN4B

Tissue Specificity: Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.

Background: Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene. The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Molecular Weight: 72 kDa

Gene ID: 8807

UniProt: O95256