GP6 antibody (C-Term)

Catalog No. ABIN7602888

This Rabbit Polyclonal antibody specifically detects GP6 in WB and FACS. It exhibits reactivity toward Mouse.

Quick Overview for GP6 antibody (C-Term) (ABIN7602888)

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GP6 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-GP6 Antibody

Binding Specificity: C-Term

Purpose: Anti-GP6 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-GP6 Antibody Picoband® (ABIN7602888). Tested in WB, Flow Cytometry applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse GP6. Mouse GP6 shares 75% amino acid (aa) sequence identity with human GP6.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
1. Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O'Donnell, E., Farndale, R. W., Ware, J., Lee, D. M. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327: 580-583, 2010. 2. Dumont, B., Lasne, D., Rothschild, C., Bouabdelli, M., Ollivier, V., Oudin, C., Ajzenberg, N., Grandchamp, B., Jandrot-Perrus, M. Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 114: 1900-1903, 2009. 3. zumi, Y., Uchiyama, T., Takayama, H. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. Biochem. Biophys. Res. Commun. 277: 27-36, 2000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for GP6

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Alternative Name: GP6

Background:

Synonyms: GP6, Platelet glycoprotein VI, GPVI, Glycoprotein 6

Background: Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway, peptidyl-tyrosine phosphorylation, and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow, femur, liver, and spleen. Human ortholog(s) of this gene implicated in blood platelet disease (multiple), coronary artery disease (multiple), and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet).

Molecular Weight: 35 kDa

Gene ID: 243816

UniProt: P0C191