CXCR7 antibody

Catalog No. ABIN7604542

The Rabbit Monoclonal anti-CXCR7 antibody has been validated for WB and FACS. It is suitable to detect CXCR7 in samples from Human, Rat and Mouse.

Quick Overview for CXCR7 antibody (ABIN7604542)

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CXCR7 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: FEI-1

Product Details anti-CXCR7 Antibody

Purpose: Anti-CXCR7 ACKR3 Rabbit Monoclonal Antibody

Characteristics: Anti-CXCR7 ACKR3 Rabbit Monoclonal Antibody (ABIN7604542). Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CXCR7

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
FC 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for CXCR7

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Alternative Name: ACKR3

Background:

Synonyms: Atypical chemokine receptor 3,C-X-C chemokine receptor type 7,CXC-R7,CXCR-7,Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog,RDC-1,ACKR3,CMKOR1, CXCR7, GPR159, RDC1,

Tissue Specificity: Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level). .

Molecular Weight: 40 kDa

UniProt: P25106

Pathways: Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling