Measles Virus Fusion Protein (MV F) (AA 451-550) antibody

Catalog No. ABIN729403

This Rabbit Polyclonal antibody specifically detects in IF (cc) and IF (p). It exhibits reactivity toward Measles Virus and Virus.

Quick Overview for Measles Virus Fusion Protein (MV F) (AA 451-550) antibody (ABIN729403)

Target: Measles Virus Fusion Protein (MV F)

Reactivity: Measles Virus, Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 451-550

Cross-Reactivity: Virus

Cross-Reactivity (Details): Measles virus

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Measles virus fusion protein

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Measles Virus Fusion Protein (MV F)

Alternative Name: Measles Virus Fusion Protein

Target Type: Viral Protein

Background:

Synonyms: Fusion glycoprotein F0, Fusion glycoprotein F1, MeV, Morbillivirus

Background: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).

Gene ID: 1489800

UniProt: P69353