CXCR1 antibody (AA 186-280)

Catalog No. ABIN730873

This Rabbit Polyclonal antibody specifically detects CXCR1 in WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human and Rat and has been mentioned in 4+ publications.

Quick Overview for CXCR1 antibody (AA 186-280) (ABIN730873)

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CXCR1 Antibody

Binding Specificity: AA 186-280

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CXCR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CXCR1 antibody (ABIN730873)

Schneberger, Gordon, DeVasure, Boten, Heires, Romberger, Wyatt: "CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice." in: Pulmonary pharmacology & therapeutics, Vol. 31, pp. 55-62, (2015) (PubMed).

Zhao, Zhu, Jiang, Xu, Wang, Chen, Liu: "Role of GPER1, EGFR and CXCR1 in differentiating between malignant follicular thyroid carcinoma and benign follicular thyroid adenoma." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11236-47, (2015) (PubMed).

Tang, Yang, Wang, Li, Xu, Chen, Liu: "High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3213-23, (2015) (PubMed).

Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3028-37, (2014) (PubMed).

Target Details for CXCR1

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Alternative Name: CXCR1

Background:

Synonyms: C-C, CD128, CD181, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1, C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, High affinity interleukin-8 receptor A, IL-8R A, IL-8 receptor type 1, CXCR1

Background: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene ID: 3577

UniProt: P25024

Pathways: cAMP Metabolic Process