APCDD1 antibody

Catalog No. ABIN731408

The Rabbit Polyclonal anti-APCDD1 antibody is suitable to detect APCDD1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC (p).

Quick Overview for APCDD1 antibody (ABIN731408)

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APCDD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APCDD1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APCDD1

Isotype: IgG

Application Details

Application Notes: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for APCDD1

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Alternative Name: Apcdd1

Background:

Synonyms: adenomatosio polyposis coli down-regulated 1, Adenomatosis polyposis coli down regulated 1, Adenomatosis polyposis coli down regulated 1 protein, APCDD 1, B7323, DRAPC1, FP7019, Protein APCDD1, APCD1_HUMAN.

Background: APCDD1 is a novel protein that has been shown to be a target of Wnt/beta catenin signaling pathway in cancer cell lines. APCDD1 is overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1 mutated Wilms tumors.[FUNCTION] Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway.[SUBCELLULAR LOCATION] Membrane, Single-pass type I membrane protein (Potential). [TISSUE SPECIFICITY] Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. [INDUCTION] Transcriptionally regulated by the CTNNB1/TF7L2complex.

Gene ID: 147495