APCDD1 antibody (Biotin)

Catalog No. ABIN731410

This Rabbit Polyclonal antibody specifically detects APCDD1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for APCDD1 antibody (Biotin) (ABIN731410)

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APCDD1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APCDD1 Antibody (Biotin)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APCDD1

Isotype: IgG

Application Details

Application Notes: WB(1:100-1000), IHC-P(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for APCDD1

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Alternative Name: Apcdd1

Background:

Synonyms: adenomatosio polyposis coli down-regulated 1, Adenomatosis polyposis coli down regulated 1, Adenomatosis polyposis coli down regulated 1 protein, APCDD 1, B7323, DRAPC1, FP7019, Protein APCDD1, APCD1_HUMAN.

Background: APCDD1 is a novel protein that has been shown to be a target of Wnt/beta catenin signaling pathway in cancer cell lines. APCDD1 is overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1 mutated Wilms tumors.[FUNCTION] Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway.[SUBCELLULAR LOCATION] Membrane, Single-pass type I membrane protein (Potential). [TISSUE SPECIFICITY] Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. [INDUCTION] Transcriptionally regulated by the CTNNB1/TF7L2complex.

Gene ID: 147495