Cadherin-16 antibody (AA 371-507) (CF®405S)

Catalog No. ABIN7650246

This anti-Cadherin-16 antibody is a Mouse Monoclonal antibody detecting Cadherin-16 in IHC and IHC (fp). Suitable for Human.

Quick Overview for Cadherin-16 antibody (AA 371-507) (CF®405S) (ABIN7650246)

Target: Cadherin-16 (CDH16)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cadherin-16 antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CDH16-2448

Product Details anti-Cadherin-16 Antibody (CF®405S)

Binding Specificity: AA 371-507

Purpose: Ksp-Cadherin / CDH16 (Renal Cell Marker)(CDH16/2448), CF405S conjugate

Characteristics: This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 371-507) of human CDH16 protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Normal kidney or renal cell carcinoma

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Cadherin-16

Target: Cadherin-16 (CDH16)

Alternative Name: CDH16

Background:

Synonyms: Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody

Gene Symbol: CDH16

Tissue Expression: Epithelial cells

Molecular Weight: 130 kDa

Gene ID: 1014

UniProt: O75309