Calretinin antibody (AA 23-242) (CF®488A)

Catalog No. ABIN7650334

This Mouse Monoclonal antibody specifically detects Calretinin in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for Calretinin antibody (AA 23-242) (CF®488A) (ABIN7650334)

Target: Calretinin (CALB2) (Calbindin 2 (CALB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calretinin antibody is conjugated to CF®488A

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CALB2-2685

Product Details anti-Calretinin Antibody (CF®488A)

Binding Specificity: AA 23-242

Purpose: Calretinin / Calbindin 2 (Mesothelioma Marker)(CALB2/2685), CF488A conjugate

Characteristics: Calretinin (also known as Calbindin 2) is a member of the troponin C superfamily. Proteins in this family have 6 EF-hand domains which bind to calcium. Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is present in subsets of neurons throughout the brain and spinal chord, including sensory ganglia. Antibodies to calretinin are useful in differentiating mesothelioma from adenocarcinomas of the lung. They can also aid in differentiating adrenal cortical neoplasms from pheochromocytomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human Calretinin (Calbindin 2) protein fragment (around aa23-242)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Brain, Testis or Mesothelioma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Calretinin

Target: Calretinin (CALB2) (Calbindin 2 (CALB2))

Alternative Name: Calbindin 2

Background:

Synonyms: Calretinin, Calbindin 2, CAB29, CAL2, CALB2, Calbindin D29K

Gene Symbol: CALB2

Tissue Expression: Neurons

Molecular Weight: 29 kDa

Gene ID: 794

UniProt: P22676