Cathepsin K antibody (AA 163-274) (CF®594)

Catalog No. ABIN7650715

This Mouse Monoclonal antibody specifically detects Cathepsin K in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for Cathepsin K antibody (AA 163-274) (CF®594) (ABIN7650715)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin K antibody is conjugated to CF®594

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CTSK-2793

Product Details anti-Cathepsin K Antibody (CF®594)

Binding Specificity: AA 163-274

Purpose: Cathepsin K (Marker of Tumor Invasiveness)(CTSK/2793), CF594 conjugate

Characteristics: Cathepsin K is a lysosomal and secreted cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human Cathepsin K protein (around aa 163-274)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Human liver or breast tissue (IHC).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K

Background:

Synonyms: Cathepsin K, Cathepsin O, Cathepsin O1, Cathepsin O2, Cathepsin X, CTSK

Gene Symbol: CTSK

Molecular Weight: 39 kDa

Gene ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades