SIPA1 antibody (AA 351-450) (FITC)

Catalog No. ABIN731910

This anti-SIPA1 antibody is a Rabbit Polyclonal antibody detecting SIPA1 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for SIPA1 antibody (AA 351-450) (FITC) (ABIN731910)

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIPA1 antibody is conjugated to FITC

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SIPA1 Antibody (FITC)

Binding Specificity: AA 351-450

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPA-1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SIPA1

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Alternative Name: Spa-1/Sipa-1

Background:

Synonyms: GTPase activating protein Spa 1, GTPase-activating protein Spa-1, MGC102688, MGC17037, p130 SPA-1, p130 SPA1, Signal induced proliferation associated 1, Signal induced proliferation associated gene 1, Signal induced proliferation associated protein 1, signal-induced proliferation-associated gene 1, Signal-induced proliferation-associated protein 1, SIPA 1, Sipa-1, Sipa1, SIPA1_HUMAN, Spa1.

Background: The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Gene ID: 6494

Pathways: Response to Water Deprivation