Recombinant Elastin antibody

Catalog No. ABIN7653439

This Rabbit Monoclonal antibody specifically detects Elastin in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for Recombinant Elastin antibody (ABIN7653439)

Target: Elastin (ELN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Elastin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: ELN-3131R

Product Details anti-Elastin Antibody

Purpose: Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis)(ELN/3131R)

Characteristics: Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries. It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticity to the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human Elastin protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Preservative: Without preservative

Storage: -20 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Elastin

Target: Elastin (ELN)

Alternative Name: Elastin

Background:

Synonyms: Elastin, ELN, SVAS, Tropoelastin, WBS, WS

Gene Symbol: ELN

Molecular Weight: 70 kDa

Gene ID: 2006

UniProt: P15502

Pathways: Regulation of Actin Filament Polymerization