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FAF1 antibody (CF®640R)

This anti-FAF1 antibody is a Mouse Monoclonal antibody detecting FAF1 in WB, IHC and IHC (fp). Suitable for Human.
Catalog No. ABIN7653912

Quick Overview for FAF1 antibody (CF®640R) (ABIN7653912)

Target

See all FAF1 Antibodies
FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This FAF1 antibody is conjugated to CF®640R

Application

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Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone

CPTC-FAF1-2
  • Purpose

    Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF640R conjugate

    Characteristics

    In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    Immunogen

    Recombinant human full-length FAF1 protein

    Isotype

    IgG2b, kappa
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Comment

    Positive Control: HEK293, MCF-7, HeLa whole cell lysate. Human testis, prostate, breast carcinoma or colon carcinoma.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.1 mg/mL

    Buffer

    PBS, 0.1 % BSA, 0.05 % azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Protect from light

    Storage

    4 °C

    Storage Comment

    Stable at room temperature or 37°C for 7 days.

    Protect from light

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    Expiry Date

    24 months
  • Target

    FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

    Alternative Name

    Fas associated factor 1

    Background

    Synonyms: CGI-03, FAS-associated factor 1, HFAF1s, UBX domain-containing protein 12, UBX domain-containing protein 3A

    Gene Symbol: FAF1

    Molecular Weight

    75-80 kDa

    Gene ID

    11124

    UniProt

    Q9UNN5

    Pathways

    Maintenance of Protein Location
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