MCAM antibody (AA 201-300) (PE)

Catalog No. ABIN732153

This anti-MCAM antibody is a Rabbit Polyclonal antibody detecting MCAM in FACS and WB. Suitable for Human and Rat. This Primary Antibody has been cited in 1 publication.

Quick Overview for MCAM antibody (AA 201-300) (PE) (ABIN732153)

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCAM antibody is conjugated to PE

Application: Flow Cytometry (FACS), Western Blotting (WB)

Product Details anti-MCAM Antibody (PE)

Binding Specificity: AA 201-300

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD146

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-MCAM antibody (PE) (ABIN732153)

Zhan, Liu, Wang: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).

Target Details for MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Alternative Name: Cd146

Background:

Synonyms: CD146, MUC18, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, MCAM

Background: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene ID: 4162

UniProt: P43121