IL-10RA antibody (CF®640R)

Catalog No. ABIN7655651

The Rat Monoclonal anti-IL-10RA antibody has been validated for FACS and Func. It is suitable to detect IL-10RA in samples from Mouse.

Quick Overview for IL-10RA antibody (CF®640R) (ABIN7655651)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-10RA antibody is conjugated to CF®640R

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: 1B1-3a

Product Details anti-IL-10RA Antibody (CF®640R)

Purpose: IL-10R1, Mouse (Interleukin-10 Receptor 1) (CD210)(1B1.3a), CF640R conjugate

Characteristics: This monoclonal antibody recognizes Mouse Interleukin-10 receptor 1 (IL-10R1), a cell surface glycoprotein of approximately 110 kDa. Its epitope is localized in the ligand-binding domain in the extracellular region of Mouse IL-10R1. This antibody blocks the binding of IL-10 to its receptor. IL-10R1 is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Purified recombinant extracellular region of Mouse IL10RA

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: MPBMC . Spleen, Thymus, Lymph Node, Placenta, Lung or Liver.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Alternative Name: IL-10R1

Background:

Synonyms: CD210 antigen, CDw210a, IBD28, IL10R alpha, IL-10R subunit 1, IL-10R1, IL10RA IL10RIL-10R subunit alpha, interleukin 10 receptor, alpha, interleukin-10 receptor alpha chain, Interleukin-10 receptor subunit 1

Tissue Expression: Lymphocytes|Monocytes/macrophages|NK cells

Molecular Weight: 90-110 kDa

Gene ID: 16154

UniProt: Q61727

Pathways: Growth Factor Binding