KRT16 antibody (C-Term) (CF®594)

Catalog No. ABIN7656004

This Mouse Monoclonal antibody specifically detects KRT16 in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for KRT16 antibody (C-Term) (CF®594) (ABIN7656004)

Target: KRT16 (Keratin 16 (KRT16))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT16 antibody is conjugated to CF®594

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: LL025

Product Details anti-KRT16 Antibody (CF®594)

Binding Specificity: C-Term

Purpose: Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker)(LL025), CF594 conjugate

Characteristics: Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I Cytokeratins (Cytokeratins 9 to 23) and one type II Cytokeratins (keratins 1 to 8). The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in non-invasive breast carcinomas and normal breast tissue. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A synthetic peptide from the C-terminal of human Cytokeratin 16

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: HeLa cells. Tonsil, Skin. Bladder, or Cervix.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for KRT16

Target: KRT16 (Keratin 16 (KRT16))

Alternative Name: Keratin 16

Background:

Synonyms: CK16, Cytokeratin-16, Focal non epidermolytic palmoplantar keratoderma (FNEPPK / NEPPK), K1CP, Keratin Type I Cytoskeletal 16, Keratin-16, KRT16A

Gene Symbol: KRT16

Tissue Expression: Epidermal cells

Molecular Weight: 48 kDa

Gene ID: 3868

UniProt: P08779