LI Cadherin antibody (AA 242-418) (CF®640R)

Catalog No. ABIN7656335

The Mouse Monoclonal anti-LI Cadherin antibody has been validated for WB, IHC and IHC (fp). It is suitable to detect LI Cadherin in samples from Human.

Quick Overview for LI Cadherin antibody (AA 242-418) (CF®640R) (ABIN7656335)

Target: LI Cadherin

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LI Cadherin antibody is conjugated to CF®640R

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CDH17-2617

Product Details anti-LI Cadherin Antibody (CF®640R)

Binding Specificity: AA 242-418

Purpose: Cadherin 17 / LI Cadherin (Liver-Intestine Marker)(CDH17/2617), CF640R conjugate

Characteristics: Cadherin 17, also known as LI cadherin (for liver-intestine cadherin), is a member of the cadherin family of calcium-dependent adhesion molecules. Cadherins mediate cell-cell interactions via hemophilic binding, and are critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. Cadherin 17 expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 242-418) of human Cadherin 17 protein (CDH17)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: HepG2 or HT29 cells. Stomach, Small Intestine, Colon or liver.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for LI Cadherin

Target: LI Cadherin

Alternative Name: Cadherin 17

Background:

Synonyms: Cadherin 17, Cadherin-17, CDH17, LI-cadherin, Liver-intestine cadherin, human peptide transporter 1 (HPT-1), Intestinal peptide-associated transporter HPT-1

Gene Symbol: CDH17

Tissue Expression: Intestine|Liver

Molecular Weight: 120 kDa

Gene ID: 1015

UniProt: Q12864