MTF1 antibody (Biotin)

Catalog No. ABIN7656976

This Mouse Monoclonal antibody specifically detects MTF1 in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for MTF1 antibody (Biotin) (ABIN7656976)

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTF1 antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: MTF1-2649

Product Details anti-MTF1 Antibody (Biotin)

Purpose: MTF1(MTF1/2649), Biotin conjugate

Characteristics: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human MTF1 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Human kidney.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Alternative Name: MTF1

Background:

Synonyms: Metal regulatory transcription factor 1, Metal response element binding transcription factor 1, Metal responsive transcription factor 1, MRE-binding transcription factor 1, MTF1, Transcription factor MTF1, Zinc regulatory factor (ZRF)

Gene Symbol: MTF1

Molecular Weight: 70 kDa

Gene ID: 4520

UniProt: Q14872